Dr. Xiaoke Yin
Dr. Xiaoke Yin got his BSc on biology in Peking University in 2000 and came to the UK to pursue his PhD degree in 2002. Since then he started to use proteomic techniques to study the cardiovascular diseases. In 2006 he was awarded PhD degree by the University of London and joined Prof. Manuel Mayr’s group at King’s College London. In 2008, he was appointed the King’s BHF centre core post for proteomics and got renewed in 2013. Now he is in charge of the proteomics facilities and oversees different projects which use LC-MS technique. He also carries out his own research projects as well as the collaborations with many other groups within KCL and internationally.
Education
| 1996-2000 | BSc, College of Life Sciences, Peking University, P. R. China |
| 2002-2006 | PhD, Medical Engineering Division, Dept. of Engineering, Queen Mary, University of London, UK |
Present Appointment
| 2023- | Research Fellow National Heart and Lung Institute Imperial College London London, UK |
Previous Appointment
| 2006-2023 | Research Associate Cardiovascular Division, King’s College London, London, UK |
| 2000-2002 | Research Assistant College of Life Sciences, Peking University, China |
Awards & Prizes
| 2005 | Clinical Science Young Investigator Award |
| 2015 | Thermo Scientific Tandem Mass Tag Research Award |
Publications
| 1 | Loos M, Klampe B, Schulze T, Yin X, Theofilatos K, Ulmer BM, Schulz C, Behrens CS, van Bergen TD, Adami E, Maatz H, Schweizer M, Brodesser S, Skryabin BV, Rozhdestvensky TS, Bodbin S, Stathopoulou K, Christ T, Denning C, Hübner N, Mayr M, Cuello F, Eschenhagen T, Hansen A. Human model of primary carnitine deficiency cardiomyopathy reveals ferroptosis as a novel mechanism. Stem Cell Reports. 2023 18(11) : 2123-2137. [Full Text] [PubMed] [DOI] |
| 2 | Malnar Črnigoj M, Čerček U, Yin X, Ho MT, Repic Lampret B, Neumann M, Hermann A, Rouleau G, Suter B, Mayr M, Rogelj B. Phenylalanine-tRNA aminoacylation is compromised by ALS/FTD-associated C9orf72 C4G2 repeat RNA. Nature communications. 2023 14(1) : 5764. [Full Text] [PubMed] [DOI] |
| 3 | Theofilatos K, Stojkovic S, Hasman M, van der Laan SW, Baig F, Barallobre-Barreiro J, Schmidt LE, Yin S, Yin X, Burnap S, Singh B, Popham J, Harkot O, Kampf S, Nackenhorst MC, Strassl A, Loewe C, Demyanets S, Neumayer C, Bilban M, Hengstenberg C, Huber K, Pasterkamp G, Wojta J, Mayr M. Proteomic Atlas of Atherosclerosis: The Contribution of Proteoglycans to Sex Differences, Plaque Phenotypes, and Outcomes. Circulation Research. 2023 133(7) : 542-558. [Full Text] [PubMed] [DOI] |
| 4 | Romeo SG, Secco I, Schneider E, Reumiller CM, Santos CX, Zoccarato A, Musale V, Pooni A, Yin X, Theofilatos K, Trevelin SC, Zeng L, Mann GE, Pathak V, Harkin K, Stitt AW, Medina RJ, Margariti A, Mayr M, Shah AM, Giacca M, Zampetaki A. Human blood vessel organoids reveal a critical role for CTGF in maintaining microvascular integrity. Nature Communications. 2023 14(1) : 5552. [Full Text] [PubMed] [DOI] |
| 5 | Ragone I, Barallobre-Barreiro J, Takov K, Theofilatos K, Yin X, Schmidt LE, Domenech N, Crespo-Leiro MG, van der Voorn SM., Vink A, van Veen TA.B., Bödör C, Merkely B, Radovits T, Mayr M. SERCA2a Protein Levels Are Unaltered in Human Heart Failure. Circulation. 2023 148(7) : 613–616. [Full Text] [PubMed] [DOI] |
| 6 | Tsui H, van Kampen S J, Han SJ, Meraviglia V, van Ham W B, Casini S, van der Kraak P, Vink A, Yin X, Mayr M, Bossu A, Marchal G A, Monshouwer-Kloots J, Eding J, Versteeg D, de Ruiter H, Bezstarosti K, Groeneweg J, Klaasen S J, van Laake L W, Jeroen A A Demmers J AA, Kops G JPL, Mummery C L, van Veen T AB, Remme CA, Bellin M, van Rooij E. Desmosomal protein degradation as an underlying cause of arrhythmogenic cardiomyopathy. Science Translational Medicine. 2023 15(688) : eadd4248. [Full Text] [PubMed] [DOI] |
| 7 | Clarke R, Von Ende A, Schmidt L E, Yin X, Hill M, Hughes A D, Pechlaner R, Willeit J, Kiechl S, Watkins H, Theofilatos K, Hopewell J C, Mayr M, PROCARDIS Consortium. Apolipoprotein Proteomics for Residual Lipid-Related Risk in Coronary Heart Disease. Circulation Research. 2023 132(4) : 452-464. [Full Text] [PubMed] [DOI] |
| 8 | Reed E, Fellows A, Lu R, Rienks M, Schmidt L, Yin X, Duregotti E, Brandt M, Krasemann S, Hartmann K, Barallobre-Barreiro J, Addison O, Cuello F, Hansen A, Mayr M. Extracellular Matrix Profiling and Disease Modelling in Engineered Vascular Smooth Muscle Cell Tissues. Matrix biology plus. 2022 16 : 100122. [Full Text] [PubMed] [DOI] |
| 9 | Yin X, Takov K, Straube R, Voit-Bak K, Graessler J, Julius U, Tselmin S, Rodionov R, Barbir M, Walls M, Theofilatos K, Mayr M, Bornstein SR. Precision Medicine Approach for Cardiometabolic Risk Factors in Therapeutic Apheresis. Hormone and Metabolic Research. 2022 54(04) : 238-249. [PubMed] [DOI] |
| 10 | Dave J, Raad N, Mittal N, Zhang L, Fargnoli A, Oh JG, Savoia ME, Hansen J, Fava M, Yin X, Theofilatos K, Ceholski D, Kohlbrenner E, Jeong D, Wills L, Nonnenmacher M, Haghighi K, Costa KD, Turnbull IC, Mayr M, Cai C-L, Kranias EG, Akar FG, Hajjar RJ, Stillitano F. Gene editing reverses arrhythmia susceptibility in humanized PLN-R14del mice: modelling a European cardiomyopathy with global impact. Cardiovascular Research. 2022 : . [Full Text] [PubMed] [DOI] |
| 11 | Ghim M, Pang KT, Burnap SA, Baig F, Yin X, Arshad M, Mayr M, Weinberg PD. Endothelial cells exposed to atheroprotective flow secrete follistatin-like 1 protein which reduces transcytosis and inflammation. Atherosclerosis. 2021 333 : 56-66. [Full Text] [PubMed] [DOI] |
| 12 | Eijgenraam TR, Boogerd CJ, Stege NM, Oliveira Nunes Teixeira V, Dokter MM, Schmidt LE, Yin X, Theofilatos K, Mayr M, van der Meer P, van Rooij E. Protein Aggregation Is an Early Manifestation of Phospholamban p.(Arg14del)-Related Cardiomyopathy: Development of PLN-R14del–Related Cardiomyopathy. Circulation: Heart Failure. 2021 : CIRCHEARTFAILURE-121. [Full Text] [PubMed] [DOI] |
| 13 | Gutmann C, Takov K, Burnap S, Singh B, Theofilatos K, Reed E, Hasman M, Nabeebaccus A, Fish M, McPhail M, O'Gallagher K, Schmidt L, Cassel C, Rienks M, Yin X, Auzinger G, Napoli S, Mujib S, Trovato F, Sanderson B, Merrick B, Niazi U, Saqi M, Dimitrakopoulou K, Braun S, Kronstein-Wiedemann R, Doores K, Edgeworth J, Shah A, Bornstein S, Tonn T, Hayday A, Shankar-Hari M, Mayr M. SARS-CoV-2 RNAemia and proteomic biomarker trajectory inform prognostication in COVID-19 patients admitted to intensive care. . 2020 : . [Full Text] [DOI] |
| 14 | Mayer L, Pechlaner R, Barallobre-Barreiro J, Boehme C, Toell T, Lynch M, Yin X, Willeit J, Gizewski ER, Perco P, Ratzinger G, Kiechl S, Mayr M, Knoflach M. Extracellular matrix protein signature of recurrent spontaneous cervical artery dissection. Neurology. 2020 95(15) : e2047-55. [Full Text] [PubMed] [DOI] |
| 15 | Hohl M, Mayr M, Lang L, Nickel AG, Barallobre-Barreiro J, Yin X, Speer T, Selejan SR, Goettsch C, Erb K, Fecher-Trost C, Reil JC, Linz B, Ruf S, Hübschle T, Maak C, Böhm M, Sadowski T, Linz D. Cathepsin A contributes to left ventricular remodeling by degrading extracellular superoxide dismutase in mice. Journal of Biological Chemistry. 2020 295(36) : 12605-12617. [Full Text] [PubMed] [DOI] |
| 16 | Pechlaner R, Posod A, Yin X, Burnap SA, Kiechl SJ, Mayr M, Kiechl S, Kiechl-Kohlendorfer U. Very preterm birth results in later lower platelet activation markers. Pediatric Research. 2020 : 1-5. [Full Text] [PubMed] [DOI] |
| 17 | Foinquinos A, Batkai S, Genschel C, Viereck J, Rump S, Gyöngyösi M, Traxler D, Riesenhuber M, Spannbauer A, Lukovic D, Weber N, Zlabinger K, Hašimbegović E, Winkler J, Fiedler J, Dangwal S, Fischer M, de la Roche J, Wojciechowski D, Kraft T, Garamvölgyi R, Neitzel S, Chatterjee S, Yin X, Bär C, Mayr M, Xiao K, Thum T. Preclinical development of a miR-132 inhibitor for heart failure treatment.. Nat Commun. 2020 11(1) : 633. [Full Text] [PubMed] [DOI] |
| 18 | Yin X, Wanga S, Fellows AL, Barallobre-Barreiro J, Lu R, Davaapil H, Franken R, Fava M, Baig F, Skroblin P, Xing Q, Koolbergen DR, Groenink M, Zwinderman AH, Balm R, de Vries CJM, Mulder BJM, Viner R, Jahangiri M, Reinhardt DP, Sinha S, de Waard V, Mayr M.. Glycoproteomic Analysis of the Aortic Extracellular Matrix in Marfan Patients.. Arterioscler Thromb Vasc Biol.. 2019 39(9) : 1859-1873. [Full Text] [PubMed] [DOI] |
| 19 | Grund A, Szaroszyk M, Korf-Klingebiel M, Malek Mohammadi M, Trogisch FA, Schrameck U, Gigina A, Tiedje C, Gaestel M, Kraft T, Hegermann J, Batkai S, Thum T, Perrot A, Remedios CD, Riechert E, Völkers M, Doroudgar S, Jungmann A, Bauer R, Yin X, Mayr M, Wollert KC, Pich A, Xiao H, Katus HA, Bauersachs J, Müller OJ, Heineke J.. TIP30 counteracts cardiac hypertrophy and failure by inhibiting translational elongation.. EMBO Mol Med.. 2019 11(10) : e10018. [Full Text] [PubMed] [DOI] |
| 20 | Posod A, Pechlaner R, Yin X, Burnap SA, Kiechl SJ, Willeit J, Witztum JL, Mayr M, Kiechl S, Kiechl-Kohlendorfer U. Apolipoprotein Profiles in Very Preterm and Term-Born Preschool Children. J Am Heart Assoc. 2019 8 : e011199. [Full Text] [PubMed] [DOI] |
| 21 | Forte A, Yin X, Fava M, Bancone C, Cipollaro M, De Feo M, Mayr M, Jahangiri M, Della Corte A. Locally different proteome in aortas from patients with stenotic tricuspid and bicuspid aortic valves. Eur J Cardiothorac Surg. 2019 Epub : ahead of print. [Full Text] [PubMed] [DOI] |
| 22 | Barwari T, Eminaga S, Mayr U, Lu R, Armstrong PC, Chan MV, Sahraei M, Fernández-Fuertes M, Moreau T, Barallobre-Barreiro J, Lynch M, Yin X, Schulte C, Baig F, Pechlaner R, Langley SR, Zampetaki A, Santer P, Weger M, Plasenzotti R, Schosserer M, Grillari J, Kiechl S, Willeit J, Shah AM, Ghevaert C, Warner TD, Fernández-Hernando C, Suárez Y, Mayr M. Inhibition of profibrotic microRNA-21 affects platelets and their releasate. JCI Insight. 2018 3 : e123335. [Full Text] [PubMed] [DOI] |
| 23 | Fava M, Barallobre-Barreiro J, Mayr U, Lu R, Didangelos A, Baig F, Lynch M, Catibog N, Joshi A, Barwari T, Yin X, Jahangiri M, Mayr M. Role of ADAMTS (A Disintegrin and Metalloproteinase With Thrombospondin Motifs)-5 in Aortic Dilatation and Extracellular Matrix Remodeling. Arterioscler Thromb Vasc Biol. 2018 38 : 1537-1548. [Full Text] [PubMed] [DOI] |
| 24 | Hermida N, Michel L, Esfahani H, Dubois-Deruy E, Hammond J, Bouzin C, Markl A, Colin H, Steenbergen AV, De Meester C, Beauloye C, Horman S, Yin X, Mayr M, Balligand JL. Cardiac myocyte β3-adrenergic receptors prevent myocardial fibrosis by modulating oxidant stress-dependent paracrine signaling. Eur Heart J. 2018 39 : 888-898. [Full Text] [PubMed] [DOI] |
| 25 | Suna G, Wojakowski W, Lynch M, Barallobre-Barreiro J, Yin X, Mayr U, Baig F, Lu R, Fava M, Hayward R, Molenaar C, White SJ, Roleder T, Milewski K, Gasior P, Buszman PP, Buszman PE, Jahangiri M, Shanahan C, Hill JM, Mayr M. Extracellular Matrix Proteomics Reveals Interplay of Aggrecan and Aggrecanases in Vascular Remodeling of Stented Coronary Arteries. Circulation. 2018 137 : 166-183. [Full Text] [PubMed] [DOI] |
| 26 | Nabeebaccus AA, Zoccarato A, Hafstad AD, Santos CX, Aasum E, Brewer AC, Zhang M, Beretta M, Yin X, West JA, Schröder K, Griffin JL, Eykyn TR, Abel ED, Mayr M, Shah AM. Nox4 reprograms cardiac substrate metabolism via protein O-GlcNAcylation to enhance stress adaptation. JCI Insight. 2017 2 : e96184. [Full Text] [PubMed] [DOI] |
| 27 | Yin X, Baig F, Haudebourg E, Blankley RT, Gandhi T, Müller S, Reiter L, Hinterwirth H, Pechlaner R, Tsimikas S, Santer P, Willeit J, Kiechl S, Witztum JL, Sullivan A, Mayr M. Plasma Proteomics for Epidemiology: Increasing Throughput With Standard-Flow Rates. Circ Cardiovasc Genet. 2017 10 : e001808. [Full Text] [PubMed] [DOI] |
| 28 | Sassi Y, Avramopoulos P, Ramanujam D, Grüter L, Werfel S, Giosele S, Brunner AD, Esfandyari D, Papadopoulou AS, De Strooper B, Hübner N, Kumarswamy R, Thum T, Yin X, Mayr M, Laggerbauer B, Engelhardt S. Cardiac myocyte miR-29 promotes pathological remodeling of the heart by activating Wnt signaling. Nat Commun. 2017 8 : 1614. [Full Text] [PubMed] [DOI] |
| 29 | Viviano A, Yin X, Zampetaki A, Fava M, Gallagher M, Mayr M, Jahangiri M. Proteomics of the epicardial fat secretome and its role in post-operative atrial fibrillation. Europace. 2017 20 : 1201-1208. [Full Text] [PubMed] [DOI] |
| 30 | Barallobre-Barreiro J, Baig F, Fava M, Yin X, Mayr M. Glycoproteomics of the Extracellular Matrix: A Method for Intact Glycopeptide Analysis Using Mass Spectrometry. J Vis Exp. 2017 122 : . [Full Text] [PubMed] [DOI] |
| 31 | Langley SR, Willeit K, Didangelos A, Matic LP, Skroblin P, Barallobre-Barreiro J, Lengquist M, Rungger G, Kapustin A, Kedenko L, Molenaar C, Lu R, Barwari T, Suna G, Yin X, Iglseder B, Paulweber B, Willeit P, Shalhoub J, Pasterkamp G, Davies AH, Monaco C, Hedin U, Shanahan CM, Willeit J, Kiechl S, Mayr M. Extracellular matrix proteomics identifies molecular signature of symptomatic carotid plaques. J Clin Invest. 2017 4 : 1546-1560. [Full Text] [PubMed] [DOI] |
| 32 | Pechlaner R, Tsimikas S, Yin X, Willeit P, Baig F, Santer P, Oberhollenzer F, Egger G, Witztum JL, Alexander VJ, Willeit J, Kiechl S, Mayr M. Very-Low-Density Lipoprotein-Associated Apolipoproteins Predict Cardiovascular Events and Are Lowered by Inhibition of APOC-III. J Am Coll Cardiol. 2017 69 : 789-800. [Full Text] [PubMed] [DOI] |
| 33 | Khan SY, Awad EM, Oszwald A, Mayr M, Yin X, Waltenberger B, Stuppner H, Lipovac M, Uhrin P, Breuss JM. Premature senescence of endothelial cells upon chronic exposure to TNFα can be prevented by N-acetyl cysteine and plumericin. Sci Rep. 2017 7 : 39501. [Full Text] [PubMed] [DOI] |
| 34 | Willeit P, Skroblin P, Moschen AR, Yin X, Kaudewitz D, Zampetaki A, Barwari T, Whitehead M, Ramírez CM, Goedeke L, Rotllan N, Bonora E, Hughes AD, Santer P, Fernández-Hernando C, Tilg H, Willeit J, Kiechl S, Mayr M.. Circulating MicroRNA-122 Is Associated With the Risk of New-Onset Metabolic Syndrome and Type 2 Diabetes. Diabetes. 2017 66 : 347-357. [Full Text] [PubMed] [DOI] |
| 35 | Barallobre-Barreiro J, Lynch M, Yin X, Mayr M. Systems Biology - Opportunities and Challenges: The Application of Proteomics to Study the Cardiovascular Extracellular Matrix. Cardiovasc Res. 2016 112 : 626-636. [Full Text] [PubMed] [DOI] |
| 36 | Barallobre-Barreiro J, Gupta SK, Zoccarato A, Kitazume-Taneike R, Fava M, Yin X, Werner T, Hirt MN, Zampetaki A, Viviano A, Chong M, Bern M, Kourliouros A, Domenech N, Willeit P, Shah AM, Jahangiri M, Schaefer L, Fischer JW, Iozzo RV, Viner R, Thum T, Heineke J, Kichler A, Otsu K, Mayr M. Glycoproteomics Reveals Decorin Peptides With Anti-Myostatin Activity in Human Atrial Fibrillation. Circulation. 2016 134 : 817-832. [Full Text] [PubMed] [DOI] |
| 37 | Bauer A, Mylroie H, Thornton CC, Calay D, Birdsey GM, Kiprianos AP, Wilson GK, Soares MP, Yin X, Mayr M, Randi AM, Mason JC. Identification of cyclins A1, E1 and vimentin as downstream targets of heme oxygenase-1 in vascular endothelial growth factor-mediated angiogenesis. Sci Rep. 2016 8 : 29417. [Full Text] [PubMed] [DOI] |
| 38 | Zervou S, Yin X, A Nabeebaccus A, O'Brien BA, L Cross R, McAndrew DJ, Atkinson RA, Eykyn TR, Mayr M, Neubauer S, Lygate CA. Proteomic and metabolomic changes driven by elevating myocardial creatine suggest novel metabolic feedback mechanisms. Amino Acids. 2016 48 : 1969-1981. [Full Text] [PubMed] [DOI] |
| 39 | Ulrich V, Rotllan N, Araldi E, Luciano A, Skroblin P, Abonnenc M, Perrotta P, Yin X, Bauer A, Leslie KL, Zhang P, Aryal B, Montgomery RL, Thum T, Martin K, Suarez Y, Mayr M, Fernandez-Hernando C, Sessa WC. Chronic miR-29 antagonism promotes favorable plaque remodeling in atherosclerotic mice. EMBO Mol Med. 2016 8 : 643-653. [Full Text] [PubMed] [DOI] |
| 40 | Barallobre-Barreiro J, Oklu R, Lynch M, Fava M, Baig F, Yin X, Barwari T, Potier D, Albadawi H, Jahangiri M, Porter K, Watkins M, Misra S, Stoughton J, Mayr M. Extracellular Matrix Remodeling in Response to Venous Hypertension: Proteomics of Human Varicose Veins. Cardiovasc Res. 2016 110 : 419-430. [Full Text] [PubMed] [DOI] |
| 41 | Grandoch M, Kohlmorgen C, Melchior-Becker A, Feldmann K, Homann S, Müller J, Kiene LS, Zeng-Brouwers J, Schmitz F, Nagy N, Polzin A, Gowert NS, Elvers M, Skroblin P, Yin X, Mayr M, Schaefer L, Tannock LR, Fischer JW. Loss of Biglycan Enhances Thrombin Generation in Apolipoprotein E-Deficient Mice: Implications for Inflammation and Atherosclerosis. Arterioscler Thromb Vasc Biol. 2016 36 : 41-50. [Full Text] [PubMed] [DOI] |
| 42 | Gomes RS, Skroblin P, Munster AB, Tomlins H, Langley SR, Zampetaki A, Yin X, Wardle FC, Mayr M. "Young at heart": Regenerative potential linked to immature cardiac phenotypes. J Mol Cell Cardiol. 2016 92 : 105-108. [Full Text] [PubMed] [DOI] |
| 43 | Kaudewitz D, Skroblin P, Bender LH, Barwari T, Willeit P, Pechlaner R, Sunderland NP, Willeit K, Morton AC, Armstrong PC, Chan MV, Lu R, Yin X, Gracio F, Dudek K, Langley SR, Zampetaki A, de Rinaldis E, Ye S, Warner TD, Saxena A, Kiechl S, Storey RF, Mayr M. Association of MicroRNAs and YRNAs With Platelet Function. Circ Res. 2016 118 : 420-432. [Full Text] [PubMed] [DOI] |
| 44 | Zampetaki A, Willeit P, Burr S, Yin X, Langley SR, Kiechl S, Klein R, Rossing P, Chaturvedi N, Mayr M. Angiogenic MicroRNAs Linked to Incidence and Progression of Diabetic Retinopathy in Type 1 Diabetes. Diabetes. 2016 65 : 216-227. [Full Text] [PubMed] [DOI] |
| 45 | Zeng L, Li Y, Yang J, Wang G, Margariti A, Xiao Q, Zampetaki A, Yin X, Mayr M, Mori K, Wang W, Hu Y, Xu Q. XBP 1-Deficiency Abrogates Neointimal Lesion of Injured Vessels Via Cross Talk With the PDGF Signaling. Arterioscler Thromb Vasc Biol. 2015 35 : 2134-2144. [Full Text] [PubMed] [DOI] |
| 46 | Nabeebaccus A, Hafstad A, Eykyn T, Yin X, Brewer A, Zhang M, Mayr M, Shah A. Cardiac-targeted NADPH oxidase 4 in the adaptive cardiac remodelling of the murine heart. Lancet. 2015 385 Suppl1 : S73. [Full Text] [PubMed] [DOI] |
| 47 | Štalekar M, Yin X, Rebolj K, Darovic S, Troakes C, Mayr M, Shaw CE, Rogelj B. Proteomic analyses reveal that loss of TDP-43 affects RNA processing and intracellular transport. Neuroscience. 2015 7 : 157. [Full Text] [PubMed] [DOI] |
| 48 | Kessler T, Zhang L, Liu Z, Yin X, Huang Y, Wang Y, Fu Y, Mayr M, Ge Q, Xu Q, Zhu Y, Wang X, Schmidt K, de Wit C, Erdmann J, Schunkert H, Aherrahrou Z, Kong W. ADAMTS-7 Inhibits Re-endothelialization of Injured Arteries and Promotes Vascular Remodeling Through Cleavage of Thrombospondin-1. Circulation. 2015 131 : 1191-1201. [Full Text] [PubMed] [DOI] |
| 49 | Kapustin AN, Chatrou ML, Drozdov I, Zheng Y, Davidson SM, Soong D, Furmanik M, Sanchis P, De Rosales RT, Alvarez-Hernandez D, Shroff R, Yin X, Muller K, Skepper JN, Mayr M, Reutelingsperger CP, Chester A, Bertazzo S, Schurgers LJ, Shanahan CM. Vascular smooth muscle cell calcification is mediated by regulated exosome secretion. Circ Res. 2015 116 : 1312-1323. [Full Text] [PubMed] [DOI] |
| 50 | Zampetaki A, Attia RQ, Mayr U, Gomes RS, Phinikaridou A, Yin X, Langley S, Willeit P, Lu R, Fanshawe B, Fava M, Barallobre-Barreiro J, Molenaar C, So PW, Abbas A, Jahangiri M, Waltham M, Botnar R, Smith A, Mayr M. Role of miR-195 in Aortic Aneurysmal Disease. Circ Res. 2014 115 : 857-866. [Full Text] [PubMed] [DOI] |
| 51 | Goedeke L, Salerno A, Ramírez CM, Guo L, Allen RM, Yin X, Langley SR, Esau C, Wanschel A, Fisher EA, Suárez Y, Baldán A, Mayr M, Fernández-Hernando C. Long-term therapeutic silencing of miR-33 increases circulating triglyceride levels and hepatic lipid accumulation in mice. EMBO Mol Med. 2014 18 : 1133-1141. [Full Text] [PubMed] [DOI] |
| 52 | Cuello F, Shankar-Hari M, Mayr U, Yin X, Marshall M, Suna G, Willeit P, Langley SR, Jayawardhana T, Zeller T, Terblanche M, Shah AM, Mayr M. Redox-state of pentraxin 3 as a novel biomarker for resolution of inflammation and survival in sepsis. Mol Cell Proteomics. 2014 13 : 2545-2557. [Full Text] [PubMed] [DOI] |
| 53 | Bang C, Batkai S, Dangwal S, Gupta SK, Foinquinos A, Holzmann A, Just A, Remke J, Zimmer K, Zeug A, Ponimaskin E, Schmiedl A, Yin X, Mayr M, Halder R, Fischer A, Engelhardt S, Wei Y, Schober A, Fiedler J, Thum T. Cardiac fibroblast-derived microRNA passenger strand-enriched exosomes mediate cardiomyocyte hypertrophy. J Clin Invest. 2014 124 : 2136-2146. [Full Text] [PubMed] [DOI] |
| 54 | Wong MM, Yin X, Potter C, Yu B, Cai H, Di Bernardini E, Xu Q. Over-expression of HSP47 augments mouse embryonic stem cell smooth muscle differentiation and chemotaxis. PloS One. 2014 16 : e86118. [Full Text] [PubMed] [DOI] |
| 55 | Xiao Q, Zhang F, Grassia G, Hu Y, Zhang Z, Xing Q, Yin X, Maddaluno M, Drung B, Schmidt B, Maffia P, Ialenti A, Mayr M, Xu Q, Ye S. Matrix Metalloproteinase-8 Promotes Vascular Smooth Muscle Cell Proliferation and Neointima Formation. Arterioscler Thromb Vasc Biol. 2014 34 : 90-98. [Full Text] [PubMed] [DOI] |
| 56 | Drozdov I, Didangelos A, Yin X, Zampetaki A, Abonnenc M, Murdoch C, Zhang M, Ouzounis CA, Mayr M, Tsoka S, Shah AM. Gene Network and Proteomic Analyses of Cardiac Responses to Pathological and Physiological Stress. Circ Cardiovasc Genet. 2013 6 : 588-597. [Full Text] [PubMed] [DOI] |
| 57 | Zeng L, Wang G, Ummarino D, Margariti A, Xu Q, Xiao Q, Wang W, Zhang Z, Yin X, Mayr M, Cockerill G, Li JY, Chien S, Hu Y, Xu Q. Histone deacetylase 3 unconventional splicing mediates endothelial-to-mesenchymal transition through transforming growth factor beta2. J Biol Chem. 2013 288 : 31853-31866. [Full Text] [PubMed] [DOI] |
| 58 | El Azzouzi H, Leptidis S, Dirkx E, Hoeks J, van Bree B, Brand K, McClellan EA, Poels E, Sluimer JC, van den Hoogenhof MM, Armand AS, Yin X, Langley S, Bourajjaj M, Olieslagers S, Krishnan J, Vooijs M, Kurihara H, Stubbs A, Pinto YM, Krek W, Mayr M, da Costa Martins PA, Schrauwen P, De Windt LJ. The Hypoxia-Inducible MicroRNA Cluster miR-199a~214 Targets Myocardial PPARdelta and Impairs Mitochondrial Fatty Acid Oxidation. Cell Metab. 2013 18 : 341-354. [Full Text] [PubMed] [DOI] |
| 59 | Abonnenc M, Nabeebaccus AA, Mayr U, Barallobre-Barreiro J, Dong X, Cuello F, Sur S, Drozdov I, Langley S, Lu R, Stathopoulou K, Didangelos A, Yin X, Zimmermann WH, Shah AM, Zampetaki A, Mayr M. Extracellular Matrix Secretion by Cardiac Fibroblasts: Role of microRNA-29b and microRNA-30c. Circ Res. 2013 113 : 1138-1147. [Full Text] [PubMed] [DOI] |
| 60 | Cheng X, Chapple SJ, Patel B, Puszyk W, Sudgen D, Yin X, Mayr M, Siow RCM, Mann GE. Gestational diabetes impairs Nrf2-mediated adaptive antioxidant defenses and redox signaling in fetal endothelial cells in utero. Diabetes. 2013 62 : 4088-4097. [Full Text] [PubMed] [DOI] |
| 61 | Heymans S, Corsten MF, Verhesen W, Carai P, van Leeuwen RE, Custers K, Peters T, Hazebroek M, Stöger L, Wijnands E, Janssen BJ, Creemers EE, Pinto YM, Grimm D, Schürmann N, Vigorito E, Thum T, Stassen F, Yin X, Mayr M, De Windt LJ, Lutgens E, Wouters K, d. Macrophage MicroRNA-155 Promotes Cardiac Hypertrophy and Failure. Circulation. 2013 128 : 1420-1432. [Full Text] [PubMed] [DOI] |
| 62 | Dalli J, Montero-Melendez T, Norling LV, Yin X, Hinds C, Haskard D, Mayr M, Perretti M. Heterogeneity in neutrophil microparticles reveals distinct proteome and functional properties. Mol Cell Proteomics. 2013 12 : 2205-2219. [Full Text] [PubMed] [DOI] |
| 63 | Barallobre-Barreiro J, Didangelos A, Yin X, Domönech N, Mayr M. A sequential extraction methodology for cardiac extracellular matrix prior to proteomics analysis. Methods Mol Biol. 2013 1005 : 215-223. [PubMed] [DOI] |
| 64 | Yin X, Bern M, Xing Q, Ho J, Viner R, Mayr M. Glycoproteomic analysis of the secretome of human endothelial cells. Mol Cell Proteomics. 2013 12 : 956-978. [Full Text] [PubMed] [DOI] |
| 65 | Yin X, Dwyer J, Langley S, Mayr U, Xing Q, Drozdov I, Nabeebaccus A, Shah A, Madhu B, Griffiths J, Edwards LM, Mayr M. Effects of Perhexiline-Induced Fuel Switch on the Cardiac Proteome and Metabolome. J Mol Cell Cardiol. 2013 55 : 27-30. [Full Text] [PubMed] [DOI] |
| 66 | Frömel T, Kohlstedt K, Popp R, Yin X, Awwad K, Barbosa-Sicard E, Thomas AC, Lieberz R, Mayr M, Fleming I. Cytochrome P4502S1: a novel monocyte / macrophage fatty acid epoxygenase in human atherosclerotic plaques. Basic Res Cardiol. 2013 108 : 319. [Full Text] [PubMed] [DOI] |
| 67 | Langley SR, Dwyer J, Drozdov I, Yin X, Mayr M. Proteomics: from single molecules to biological pathways. Cardiovasc Res. 2013 97 : 612-622. [Full Text] [PubMed] [DOI] |
| 68 | Xiao Q, Zhang F, Lin L, Fang C, Wen G, Tsai TN, Pu X, Sims D, Zhang Z, Yin X, Thomaszewski B, Schmidt B, Mayr M, Suzuki K, Xu Q, Ye S. A Functional Role of Matrix Metalloproteinase-8 in Stem/Progenitor Cell Migration and Their Recruitment into Atherosclerotic Lesions. Circ Res. 2013 112 : 35-47. [Full Text] [PubMed] [DOI] |
| 69 | Bern M, Becker C, Tang W, Yong JK, Yin X, Mayr M, Khoo KH, Viner R. Search Strategies for Glycopeptide Identification. J Biomol Tech. 2013 24 : S33. [Full Text] |
| 70 | Randriamboavonjy V, Isaak J, Elgheznawy A, Pistrosch F, Frömel T, Yin X, Badenhoop K, Heide H, Mayr M, Fleming I. Calpain inhibition stabilizes the platelet proteome and reactivity in diabetes. Blood. 2012 120 : 415-423. [Full Text] [PubMed] [DOI] |
| 71 | Hergenreider E, Heydt S, Tréguer K, Boettger T, Horrevoets AJ, Zeiher AM, Scheffer MP, Frangakis AS, Yin X, Mayr M, Braun T, Urbich C, Boon RA, Dimmeler S. Atheroprotective communication between endothelial cells and smooth muscle cells through miRNAs. Nat Cell Biol. 2012 14 : 249-256. [Full Text] [PubMed] [DOI] |
| 72 | Didangelos A, Yin X, Mayr M. Method for Protein Subfractionation of Cardiovascular Tissues Before DIGE Analysis. Methods Mol Biol. 2012 854 : 287-297. [PubMed] [DOI] |
| 73 | Barallobre-Barreiro J, Didangelos A, Schoendube FA, Drozdov I, Yin X, Fernández-Caggiano M, Willeit P, Puntmann VO, Aldama-Lápez G, Shah AM, Doménech N, Mayr M. Proteomics Analysis of Cardiac Extracellular Matrix Remodeling in a Porcine Model of Ischemia-Reperfusion Injury. Circulation. 2012 125 : 789-802. [Full Text] [PubMed] [DOI] |
| 74 | Tiburcy M, Didié M, Boy O, Christalla P, Döker S, Naito H, Karikkineth BC, El-Armouche A, Grimm M, Nose M, Eschenhagen T, Zieseniss A, Katschinksi DM, Hamdani N, Linke WA, Yin X, Mayr M, Zimmermann WH. Terminal differentiation, advanced organotypic maturation, and modeling of hypertrophic growth in engineered heart tissue. Circ Res. 2011 109 : 1105-1114. [Full Text] [PubMed] [DOI] |
| 75 | Kourliouros A, Yin X, Didangelos A, Hosseini MT, Valencia O, Mayr M, Jahangiri M. Substrate modifications precede the development of atrial fibrillation after cardiac surgery: a proteomic study. Ann Thorac Surg. 2011 92 : 104-110. [Full Text] [PubMed] [DOI] |
| 76 | Xiao Q, Wang G, Yin X, Luo Z, Margariti A, Zeng L, Mayr M, Ye S, Xu Q. Chromobox Protein Homolog 3 Is Essential for Stem Cell Differentiation to Smooth Muscles In Vitro and in Embryonic Arteriogenesis. Arterioscler Thromb Vasc Biol. 2011 31 : 1842-1852. [Full Text] [PubMed] [DOI] |
| 77 | Golinska M, Troy H, Chung YL, McSheehy PMJ, Mayr M, Yin X, Ly L, Williams KJ, Airley R, Harris AL, Latigo J, Perumal M, Aboagye E, Perrett D, Stubbs M, Griffiths JR. Adaptation to HIF-1 deficiency by upregulation of the AMP/ATP ratio and phosphofructokinase activation in hepatomas. BMC Cancer. 2011 11 : 198. [Full Text] [PubMed] [DOI] |
| 78 | Didangelos A, Yin X, Mandal K, Saje A, Smith A, Xu Q, Jahangiri M, Mayr M. Extracellular matrix composition and remodeling in human abdominal aortic aneurysms: a proteomics approach. Mol Cell Proteomics. 2011 10 : M111.00812. [Full Text] [PubMed] [DOI] |
| 79 | Mayr M, May D, Oren G, Madhu B, Gilon D, Yin X, Xing Q, Drozdov I, Ainali C, Tsoka S, Xu Q, Griffiths J, Horrevoets A, Keshet E. Metabolic homeostasis is maintained in myocardial hibernation by adaptive changes in the transcriptome and proteome. J Mol Cell Cardiol. 2011 50 : 982-990. [Full Text] [PubMed] [DOI] |
| 80 | Urbich C, De Souza A, Rossig L, Yin X, Xing Q, Prokopi M, Drozdov I, Steiner M, Breuss J, Xu Q, Dimmeler S, Mayr M. Proteomic characterisation of human early pro-angiogenic cells. J Mol Cell Cardiol. 2010 50 : 333-336. [Full Text] [PubMed] [DOI] |
| 81 | Didangelos A, Yin X, Mandal K, Baumert M, Jahangiri M, Mayr M. Proteomic characterization of extracellular spaceComponents in the human aorta. Mol Cell Proteomics. 2010 9 : 2048-2062. [Full Text] [PubMed] [DOI] |
| 82 | Fleissner F, Jazbutyte V, Fiedler J, Gupta SK, Yin X, Xu Q, Galuppo P, Kneitz S, Mayr M, Ertl G, Bauersachs J, Thum T. Asymmetric Dimethylarginine Impairs Angiogenic Progenitor Cell Function in Patients With Coronary Artery Disease Through a MicroRNA-21-Dependent Mechanism. Circ Res. 2010 107 : 138-143. [Full Text] [PubMed] [DOI] |
| 83 | Margariti A, Zampetaki A, Xiao Q, Zhou B, Karamariti E, Martin D, Yin X, Mayr M, Li H, Zhang Z, De Falco E, Hu Y, Cockerill G, Xu Q, Zeng L. Histone Deacetylase 7 Controls Endothelial Cell Growth Through Modulation of beta-Catenin. Circ Res. 2010 106 : 1202-1211. [Full Text] [PubMed] [DOI] |
| 84 | Yin X, Cuello F, Mayr U, Hao Z, Hornshaw M, Ehler E, Avkiran M, Mayr M. Proteomic analysis of the cardiac myofilament subproteome reveals dynamic alterations in phosphatase subunit distribution. Mol Cell Proteomics. 2010 9 : 497-509. [Full Text] [PubMed] [DOI] |
| 85 | Mayr M, Grainger D, Mayr U, Leroyer AS, Leseche G, Sidibe A, Herbin O, Yin X, Gomes A, Madhu B, Griffiths JR, Xu Q, Tedgui A, Boulanger CM. Proteomics, Metabolomics, and Immunomics on Microparticles Derived from Human Atherosclerotic Plaques. Circ Cardiovasc Genet. 2009 2 : 379-388. [Full Text] [PubMed] [DOI] |
| 86 | Tunica DG, Yin X, Sidibe A, Stegemann C, Nissum M, Zeng L, Brunet M, Mayr M. Proteomic analysis of the secretome of human umbilical vein endothelial cells using a combination of free-flow electrophoresis and nanoflow LC-MS/MS. Proteomics. 2009 9 : 4991. [Full Text] [PubMed] [DOI] |
| 87 | Jacquet S, Yin X, Sicard P, Clark J, Skanaganayagam GS, Mayr M, Marber MS. Identification of cardiac myosin binding protein C as a candidate biomarker of myocardial infarction by proteomic analysis. Mol Cell Proteomics. 2009 8 : 2687-2699. [Full Text] [PubMed] [DOI] |
| 88 | Pula G, Mayr U, Evans C, Prokopi M, Vara DS, Yin X, Astroulakis Z, Xiao Q, Hill J, Xu Q, Mayr M. Proteomics identifies thymidine phosphorylase as a key regulator of the angiogenic potential of colony-forming units and endothelial progenitor cell cultures. Circ Res. 2009 104 : 32-40. [Full Text] [PubMed] [DOI] |
| 89 | Mayr M, Zampetaki A, Sidibe A, Mayr U, Yin X, De Souza AI, Chung YL, Madhu B, Quax PH, Hu Y, Griffiths JR, Xu Q. Proteomic and Metabolomic Analysis of Smooth Muscle Cells Derived From the Arterial Media and Adventitial Progenitors of Apolipoprotein E-Deficient Mice. Circ Res. 2008 102 : 1046-1056. [Full Text] [PubMed] [DOI] |
| 90 | Mayr M, Yusuf S, Weir G, Chung Y-L, Mayr U, Yin X, Ladroue C, Madhu B, Roberts N, De Souza A, Fredericks S, Stubbs M, Griffiths JR, Jahangiri M, Xu Q, Camm JA. Combined metabolomic and proteomic analysis of human atrial fibrillation. J Am Coll Cardiol. 2008 51 : 585-594. [Full Text] [PubMed] [DOI] |
| 91 | Sidibe A, Yin X, Tarelli E, Xiao Q, Zampetaki A, Xu Q, Mayr M. Integrated Membrane Protein Analysis of Mature and Embryonic Stem Cell-derived Smooth Muscle Cells using a Novel Combination of Cy-dye/Biotin Labelling. Mol Cell Proteomics. 2007 6 : 1788-1797. [Full Text] [PubMed] [DOI] |
| 92 | Cuello F, Bardswell SC, Haworth RS, Yin X, Lutz S, Wieland T, Mayr M, Kentish JC, Avkiran M. Protein Kinase D Selectively Targets Cardiac Troponin I and Regulates Myofilament Ca2+ Sensitivity in Ventricular Myocytes. Circ Res. 2007 100 : 864-873. [Full Text] [PubMed] [DOI] |
| 93 | Yin X, Mayr M, Xiao Q, Wang W, Xu Q. Proteomic Analysis Reveals Higher Demand for Antioxidant Protection in Embryonic Stem Cell-derived Smooth Muscle Cells. Proteomics. 2006 6 : 6437-6446. [Full Text] [PubMed] [DOI] |
| 94 | Mayr U, Mayr M, Yin X, Begum S, Tarelli E, Wait R, Xu Q. Proteomic dataset of mouse aortic smooth muscle cells. Proteomics. 2005 5 : 4546-4557. [Full Text] [PubMed] [DOI] |
| 95 | Yin X, Mayr M, Xiao Q, Mayr U, Tarelli E, Wait R, Wang W, Xu Q. Proteomic dataset of Sca-1+ progenitor cells. Proteomics. 2005 5 : 4533-4545. [Full Text] [PubMed] [DOI] |
| 96 | Mayr M, Chung YL, Mayr U, Yin X, Ly L, Troy H, Fredericks S, Hu Y, Griffiths JR, Xu Q. Proteomic and Metabolomic Analyses of Atherosclerotic Vessels From Apolipoprotein E-Deficient Mice Reveal Alterations in Inflammation, Oxidative Stress, and Energy Metabolism. Arterioscler. Thromb. Vasc. Biol. 2005 25 : 2135-2142. [Full Text] [PubMed] [DOI] |
| 97 | Mayr M, Mayr U, Chung Y-L, Yin X, Griffiths JR, Xu Q. Vascular proteomics: linking proteomic and metabolomic changes. Proteomics. 2004 4 : 3751-3761. [Full Text] [PubMed] [DOI] |